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Консультация № 188865
01.03.2016, 12:17
0.00 руб.
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Уважаемые эксперты! Пожалуйста, ответьте на вопрос:
Аденоассоциированный вирус (AAV) можно сделать хелпер-фри AAV в виде рекомбинантного хелпер-фри AAV или rAAV. Однако при введении в организм через вену rAAV быстро уничтожается иммунной системой, а попавшие в клетки векторы как правило не интегрируются в хромосомы, а существуют в виде плазмид.
Как получить rAAV, который не будет уничтожаться иммунной системой и будет интегрироваться в хромосомы клеток ?
Аденоассоциированный вирус (AAV) можно сделать хелпер-фри AAV в виде рекомбинантного хелпер-фри AAV или rAAV. Однако при введении в организм через вену rAAV быстро уничтожается иммунной системой, а попавшие в клетки векторы как правило не интегрируются в хромосомы, а существуют в виде плазмид.
Как получить rAAV, который не будет уничтожаться иммунной системой и будет интегрироваться в хромосомы клеток ?
Обсуждение
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